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Understanding Cell Fate Determination in the Immune System
Dr. John Chang 
 
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John ChangAs a postdoctoral fellow, John Chang observed that T lymphocytes appear to undergo asymmetric division during immune responses against microbial pathogens.  The discovery of asymmetric T lymphocyte division was recognized as one of the "Top Ten Scientific Breakthroughs of 2007" by Science.  John is the recipient of several awards, including the NIH Director's New Innovator Award, and is currently funded by the Howard Hughes Medical Institute and the National Institutes of Health.  

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A central problem faced by multi-cellular organisms is the need for rare progenitor cells to continually produce terminally differentiated cells while also preserving a self-renewing lineage.  In the mammalian immune system, T lymphocytes face a similar need for simultaneous differentiation and regeneration.  The goal of our research is to understand what mechanisms allow a progenitor cell to give rise to two daughter cells that adopt such different fates, using the T lymphocyte as a model system.

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Lab Location
University of California, San Diego
Leichtag Biomedical Research Building
Room 149G

Mailing Address
University of California, San Diego
9500 Gilman Drive #0726
La Jolla, CA 92093-0726

Phone: (858) 822-7568
Fax: (858) 822-7652

 

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